+44 (0)1603 592959 (office) / +44 (0)1603 592239 (lab)

  • Overview of Research

    A central theme of research work carried out in the lab is the microbiology of methanotrophic and methylotrophic bacteria. These are bacteria which can grow on one-carbon (C1) compounds such as methane, methanol, methylated amines, methanesulfonate, dimethylsulfide and methyl halides. Activities range from the enrichment, isolation and characterisation of novel organisms from a wide variety of environments including soils, seawater, landfill, hot springs, soda lakes, acidic peat bogs and the rhizosphere, through to their characterisation at the physiological, biochemical and molecular level. Key enzymes, particularly oxygenases are being purified, the genes encoding these enzymes cloned and the regulation of expression of metabolic pathways is also being examined. The ecology of these microorganisms is also being studied using DNA stable isotope probing, Raman microspectroscopy, single cell genomics, metatranscriptomics and metagenomics techniques in order to establish their role in biogeochemical cycling of C1 compounds and other atmospheric trace gases. An exciting new project funded through an ERC Advanced Grant involves the bacterial metabolism of isoprene where we are investigating the physiology, biochemistry molecular biology and ecology of isoprene degraders in the terrestrial environment.